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Name
|
L - Histidine
|
|---|---|
|
Synonyms
|
(s)-1h-imidazole-4-alanin;(s)-1h-imidazole-4-propanoicaci;
(s)-4-(2-amino-2-carboxyethyl)imidazole;
(s)-alpha-amino-1h-imidazole-4-propanoicacid;
1H-Imidazole-4-propanoic acid, alpha-amino-, (S)-;
3-(1h-imidazol-4-yl)-l-alanin;
4-(2-Amino-2-carboxyethyl)imidazole;
L-HISTIDINE BASE
|
|
CAS Number
|
71 - 00 - 1
|
|
Molecular Formula
|
C6H9N3O2
|
|
Molecular Weight
|
155.15
|
|
EINECS Number
|
200 - 745 - 3
|
|
Melting Point
|
282 °C (dec.) (lit.)
|
|
Specific Rotation
|
12.4 ° (c=11, 6N HCl)
|
|
Boiling Point
|
278.95°C (rough estimate)
|
|
Density
|
1.3092 (rough estimate)
|
|
Bulk Density
|
430 kg/m³
|
|
FEMA
|
3694
|
|
Refractive Index
|
13 ° (C=11, 6mol/L HCl)
|
|
Storage Conditions
|
2-8°C
|
|
Solubility
|
H₂O: 50 mg/mL
|
|
Form
|
Powder
|
|
Acid Dissociation Constant (pKa)
|
1.8 (at 25°C)
|
|
Color
|
White to off-white or pale yellow
|
|
pH Range for Acid-Base Indicator
|
7 - 8 at 15.5 g/l at 25 °C
|
|
Odor
|
Odorless
|
|
pH Value
|
7.0-8.0 (25°C, 0.1M in H₂O)
|
|
Optical Rotation
|
[α]²⁰/D 39±1°, c = 2% in H₂O
|
|
Odor Type
|
odorless
|
|
Biological Source
|
non-animal source
|
|
Water Solubility
|
41.6 g/L (25 °C)
|
|
Usage
|
It is used in biochemical research and in medicine for treating gastric ulcers, anemia, allergies, etc.
It belongs to amino acid drugs. As a main component of amino acid infusions and compound amino acid preparations, it is used to treat gastric ulcers, anemia, and cardiovascular system diseases such as angina pectoris, aortitis, and cardiac insufficiency. Adverse reactions and contraindications: Low toxicity; the toxic dose for adults is >64g/day. Injection of histidine hydrochloride may cause headache, flushing, and a feeling of heat. It is used as a nutritional fortifier and is an important component of amino acid infusions and compound amino acid preparations. It can be used to treat gastric ulcers and is also used in biochemical research. It is used as a pharmaceutical raw material and food additive. |
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