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Name
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(2-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)phenyl)boronic acid
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Synonyms
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(2-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)phenyl)boronic acid;
(2-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)phenyl)boronic acid;
Boronic acid, B-[2-[(4,5-dimethyl-3-isoxazolyl)(methoxymethyl)amino]sulfonyl]phenyl;
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CAS
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415697-58-4
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MF
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C₁₃H₁₇BN₂O₆S
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MW
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340.16
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Usage
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Intermediate for kinase inhibitor R&D: As a key pharmaceutical intermediate with a boronic acid structure, its boronic acid group can be introduced into target molecules through Suzuki coupling reactions, facilitating the synthesis of tumor-related kinase inhibitors such as epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibitors, and providing a structural basis for the development of precision anticancer drugs.
Molecular scaffold for anti-inflammatory drugs: The isoxazole ring and sulfamoyl group in the structure possess potential anti-inflammatory activity. Structural modification can regulate the compound's inhibitory effect on inflammatory pathways, enabling the development of novel drugs for autoimmune diseases such as rheumatoid arthritis and ulcerative colitis.
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