Ceftezole Sodium Basic information
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Product Name: |
Ceftezole Sodium |
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Synonyms: |
8-oxo-7-((1h-tetrazol-1-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci; CEFTEZOLESODIUM;8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidmonosodiumsalt;Alomen;Falomesin (6R)-7α-[[(1H-Tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidsodiumsalt; |
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CAS: |
41136-22-5 |
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MF: |
C13H11N8NaO4S3 |
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MW: |
462.46 |
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EINECS: |
1592732-453-0 |
Ceftezole Sodium Physical and Chemical Properties
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Density |
2.09 g/cm3 |
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Storage Condition |
Low temperature ventilation and drying in warehouse |
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Character |
White to light yellow crystalline powder, odorless, with moisture |
Ceftezole Sodium Indications
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Indications |
Respiratory system infection, urinary system infection, sepsis, peritonitis |
Ceftezole sodium is a semi synthetic derivative of cephalosporin. Its mechanism of action is to exert antibacterial activity by inhibiting the synthesis of bacterial cell wall. It has antibacterial activity against the following bacteria: 1. Aerobic gram positive bacteria: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes; 2. Aerobic gram negative bacteria: Escherichia coli, Klebsiella pneumoniae, proteus
It is widely distributed in the body, with the highest in kidney, followed by serum, liver, lung, heart and spleen. There is also a small amount of distribution in cerebrospinal fluid, but the distribution is significantly increased in meningitis. Compared with cefazolin, cefotaxime and cefotaxime, the distribution of Ceftezole in the inflammatory exudate was the highest. There was still a considerable amount of Ceftezole in the exudate 5 hours after administration, which was significantly longer than that in the blood.
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