L-Hydroxyproline Basic information
|
Product Name: |
L-Hydroxyproline |
|
Synonyms: |
H-HYP-OH;H-HYP-OH (TRANS);H-L-HYDROXYPROLINE;H-L-HYP-OH;H-TRANS-HYP-OH;HYDROXYPROLINE;HYDROXY-L-PROLINE;HYDROXY-L-PROLINE, TRANS-4- |
|
CAS: |
51-35-4 |
|
MF: |
C5H9NO3 |
|
MW: |
131.13 |
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EINECS: |
200-091-9 |
L-Hydroxyproline Chemical Properties
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Melting point |
273 °C (dec.)(lit.) |
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Alpha |
-75.5 º (c=5, H2O) |
|
Boiling point |
242.42°C (rough estimate) |
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Density |
1.3121 (rough estimate) |
| Vapor density | 4.5 (vs air) |
|
Refractive index |
-75.5 ° (C=4, H2O) |
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Storage temp. |
Store below +30℃ |
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Solubility |
H2O: 50 mg/mL |
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Form |
Crystals or Crystalline Powder |
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Pka |
1.82, 9.66(at 25℃) |
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Color |
White |
| Odor | Odorless |
|
PH |
5.5-6.5 (50g/l, H2O, 20℃) |
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Optical activity |
[α]25/D 75.6°, c = 1 in H2O |
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Water Solubility |
357.8 g/L (20 º C) |
|
Merck |
14,4840 |
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BRN |
471933 |
L-Hydroxyproline Usage And Synthesis
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Chemical Properties |
White crystalline powder |
|
Uses |
A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. |
L-Hydroxyproline Specification
|
Character |
White clystals or crystalline powder |
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Specific rotation[ɑ]D20 |
-74.0°~-77.0° |
|
State of Solution(Transmittance) |
Not less than 95.0% |
|
Chloride(Cl) |
≤0.02% |
|
Ammonium(NH4) |
≤0.02% |
|
Sulfate(SO4) |
≤0.02% |
|
Iron(Fe) |
≤10 ppm |
|
Arsenic(As2O3) |
≤1 ppm |
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Heavy metals(Pb) |
≤10 ppm |
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Loss on drying |
≤0.20% |
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Residue on ignition(sulfated) |
≤0.10% |
|
Assay |
98.5-101.0% |
|
pH |
5.0-6.5 |
One of the preparation methods: gelatin, bone glue, casein, soybean epidermis and other proteins are hydrolyzed with hydrochloric acid, and the iminosine is extracted by nitrosation, and then purified and crystallized by resin chromatography. The yield is about 7.0%
Often used as a flavor enhancer; a nutritional fortifier. Fragrance. Mainly used for fruit juice, refreshing drinks, nutritious drinks, etc.
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